Research Summary
Researchers developed inflammation-triggered self-immolative conjugates designed to deliver peptides orally by protecting them from gastrointestinal degradation and enhancing intestinal absorption in an animal model. The conjugates were engineered to release their peptide payload specifically in response to inflammatory markers present in the gastrointestinal tract, potentially enabling oral administration of peptides like KPV that are normally destroyed by stomach acid and digestive enzymes. This is an animal model study published in *Science Advances*.