This review article examined the current evidence on tripeptides, particularly KPV (lysine-proline-valine), in wound healing and skin regeneration by synthesizing findings from multiple studies across different research models. The review found that tripeptides demonstrate anti-inflammatory and tissue-regenerative properties through various mechanisms, with evidence spanning in vitro studies, animal models, and limited human clinical applications. This is a **review article** synthesizing existing literature rather than primary research evidence.