This review article examines BPC-157, a naturally occurring 15-amino acid peptide, and its proposed cytoprotective mechanisms in the gastrointestinal tract (evidence level: review). The authors discuss evidence suggesting BPC-157 may protect GIT tissues through multiple pathways, though the review synthesizes existing literature rather than presenting new experimental data. As a narrative review, this represents a lower evidence level compared to primary human clinical trials or controlled animal studies.