Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

This human clinical study examined whether pulsatile growth hormone secretion patterns persist when using CJC-1295, a long-acting growth hormone-releasing hormone analog, administered as continuous stimulation. The researchers found that pulsatile GH secretion was maintained despite the continuous nature of CJC-1295 stimulation, demonstrating that the body’s natural rhythmic GH release pattern is preserved with this compound. This evidence comes from a human clinical trial design.