This research review examines how activating estrogen-related receptors (ERRα/β/γ) can mimic the beneficial effects of physical exercise at the molecular level. The study focuses on SLU-PP-332, a compound that targets these receptors to potentially provide exercise-like metabolic benefits for patients who cannot engage in regular physical activity. This pharmacological approach could help address chronic diseases linked to sedentary lifestyles by activating the same cellular pathways that exercise normally triggers. The research suggests promise for treating metabolic dysfunction in physically inactive patients.
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SLU-PP-332 activates ERR pathways mimicking exercise metabolism, relevant for sedentary or mobility-limited patients.