This animal study tested a combination of NMN (which boosts NAD+ levels) and apigenin (which prevents NAD+ breakdown) in aging mice. The combination helped preserve muscle mass, bone density, and cartilage health while improving exercise capacity. The treatment worked by maintaining cellular energy levels and supporting healthy gut bacteria that produce beneficial metabolites.
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NMN plus apigenin preserved muscle, bone, and cartilage in aging mice, suggesting combinatorial NAD+ support may benefit musculoskeletal aging in practice.