This animal study found that a high-fat diet increases alpha-ketoglutarate levels, which triggers a chain reaction that depletes NAD+ and NMN levels in immune cells. This depletion disrupts cellular energy production and increases inflammation, contributing to atherosclerosis (plaque buildup in arteries). The research suggests that maintaining adequate NAD+ and NMN levels may be important for cardiovascular health and controlling inflammation.
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High-fat diet raises alpha-ketoglutarate, depleting NAD+ and NMN in immune cells—supporting NMN repletion as a strategy to moderate cardiovascular inflammation.