This peer-reviewed study demonstrates that NMN, an NAD+ precursor, protects against age-related cognitive decline in mice by reducing oxidative stress, suppressing neuroinflammation, and modulating gut microbiota composition toward butyrate-producing bacteria. The mechanism involves activation of the Nrf2/HO-1 antioxidant pathway and increased antioxidant enzyme activity in the hippocampus. These findings support NMN as a therapeutic strategy for age-related neurodegeneration via gut-brain axis modulation at doses of 300-500 mg/kg.
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NMN reduced oxidative stress and improved cognition in aging mice via gut microbiota shifts; supports gut-brain axis discussion with patients.