This study demonstrates a microneedle patch combining copper-porphyrin compounds with GSH synthesis inhibitors to enhance photodynamic therapy for diabetic wound biofilms. The research shows that blocking both GSH depletion and synthesis simultaneously amplifies ROS generation, effectively killing biofilm bacteria while promoting healing through copper-mediated angiogenesis. The findings are relevant to practitioners treating chronic diabetic wounds, as they highlight copper’s dual role in antimicrobial efficacy and tissue regeneration—mechanistically aligned with GHK-Cu’s known angiogenic and healing properties.
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Copper’s dual role in antimicrobial activity and angiogenesis in wound models supports GHK-Cu’s tissue-regenerative profile in chronic wound care.