This study found that aging causes an energy crisis in the intestines that disrupts production of HDL3, a beneficial cholesterol that protects the liver from inflammation. Supplementing with NMN restored intestinal energy production and HDL3 levels, which helped reduce liver damage and inflammation associated with aging. The research suggests NMN may help maintain healthy gut-liver communication as we age.
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NMN restored intestinal NAD+ and HDL3 in aging models, suggesting gut-liver axis support worth discussing with patients concerned about age-related metabolic decline.