Development of Freeze-Dried Hyaluronic Acid Sheets for Healing Oral Mucositis: Influence of Hyaluronic Acid Molecular Weight and Nicotinamide Mononucleotide Loading on Healing Efficacy.
Researchers tested different formulations of hyaluronic acid sheets loaded with NMN to treat severe mouth sores that occur during cancer treatment. They found that 800 kDa hyaluronic acid sheets provided the best healing results in animal studies. The NMN-loaded sheets stayed in place well and released the compound steadily, showing promise as a safe treatment for painful mouth ulcers in cancer patients.