This review article compared the anti-aging mechanisms of pyrroloquinoline quinone (PQQ) and nicotinamide-based compounds (NMN/NR), examining their effects on cellular processes and exploring potential synergistic benefits of combined use (evidence level: review of existing literature). The analysis evaluated how these compounds influence mitochondrial function, NAD+ metabolism, and oxidative stress pathways that are implicated in aging processes. The review synthesizes existing research to discuss the theoretical rationale for combining these compounds, though it does not present new primary data on their combined efficacy.