Researchers developed a copper-peptide hydrogel scaffold that combines antibacterial, antioxidant, and bone-regenerative properties for treating infected bone defects. The material showed >99% efficacy against resistant bacteria (MRSA, Pseudomonas), reduced oxidative stress, and promoted osteoblast differentiation and new bone formation in rat models. This demonstrates a metal-peptide coordination strategy relevant to GHK-Cu’s known copper-dependent mechanisms in tissue repair and antimicrobial activity.
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Cu2+-peptide coordination supports antibacterial and osteogenic activity, reinforcing copper’s role in GHK-Cu tissue repair mechanisms.