This randomized controlled trial investigated whether intraoperative methylene blue administration reduces postoperative delirium in elderly patients undergoing joint replacement surgery. The study found that methylene blue treatment was associated with a lower incidence of postoperative delirium compared to control, with specific reductions in both the rate and severity of delirium during the postoperative period. This evidence is from a human clinical trial, representing a higher level of evidence for clinical outcomes.
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