This human tissue study demonstrates that BPC-157 produces concentration-dependent vasodilation in human internal mammary artery rings, with the effect significantly dependent on endothelial nitric oxide (NO) signaling. The research shows BPC-157’s relaxant effect is substantially greater in endothelium-intact tissue and is largely blocked by NOS inhibition, confirming the NO-mediated mechanism in human vascular tissue—a critical gap filled from prior animal-only data. This is the first functional evidence of BPC-157’s vasodilatory mechanism in human arterial tissue, strengthening the scientific foundation for cardiovascular and vascular health claims.
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BPC-157 shows endothelium-dependent NO-mediated vasodilation in human arterial tissue, supporting vascular tone discussions.