This review paper explores how lung inflammation releases bioactive peptides called matrikines into circulation, which can cross into the brain and affect neurological function. The study specifically highlights GHK (part of Annular’s GHK-Cu compound) as one of several peptides that may modulate brain health when released from lung tissue during chronic inflammatory conditions like COPD. The research suggests these lung-derived peptides create a communication pathway between diseased lungs and the brain, potentially contributing to neurodegeneration and stroke risk.
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New research shows GHK peptides naturally circulate from inflamed lung tissue to modulate brain health, supporting targeted peptide therapy for patients with chronic respiratory conditions.