An older study found that methylene blue did not discolor breast milk when given to nursing mothers, suggesting it may not pass into milk since the drug is 94% protein bound. However, current safety guidelines still recommend stopping breastfeeding during treatment and for 8 days after based on the drug’s 24-hour half-life. There is no available safety data specifically for oral methylene blue use during breastfeeding.
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Methylene blue appears minimally transferred into breast milk, but current guidelines recommend cessation during treatment and 8 days after.