This review examines how exercise mimetic compounds like SLU-PP-332 could help prevent and treat Alzheimer’s disease by improving cellular energy production. When brain cells can’t produce energy properly, it leads to the brain damage seen in Alzheimer’s. These compounds work by activating the same cellular pathways that exercise does, potentially offering benefits for patients who can’t exercise regularly. This suggests exercise mimetics could be a practical intervention for cognitive decline.
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SLU-PP-332 may support mitochondrial function in neurons, relevant for patients with limited exercise capacity and cognitive concerns.