This study demonstrates that Liriope platyphylla root extract alleviates DSS-induced ulcerative colitis in mice through suppression of inflammatory cytokines, inhibition of NF-κB and MAPK signaling pathways, and modulation of gut microbiota composition. The findings position natural plant compounds as potential therapeutic alternatives to conventional UC treatments, operating through well-characterized anti-inflammatory and microbiota-balancing mechanisms. This is relevant to Annular’s peptide portfolio because BPC-157 shares similar mechanistic targets (NF-κB inhibition, gut barrier restoration, microbiota modulation) in inflammatory bowel disease models, supporting a complementary or comparative positioning strategy.
For your business
Plant extract reduced colitis markers via NF-κB/MAPK suppression—pathways BPC-157 also targets, informing multi-modal gut support strategies.