Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex via activation of SIRT1 in airway epithelial cells.

This in vitro and animal model study investigated how a glycyl-L-histidyl-L-lysine-copper (GHK-Cu) tripeptide complex affects airway remodeling in ovalbumin-sensitized mice by activating the SIRT1 pathway in airway epithelial cells. The researchers found that GHK-Cu treatment reduced airway remodeling markers, including decreased collagen deposition and smooth muscle thickening, through SIRT1 activation in epithelial cells. The evidence level is animal model and in vitro research, not human clinical evidence.