A new study in European Heart Journal shows that declining NAD+ levels with age contribute to calcific aortic valve disease by disrupting cellular metabolism and promoting inflammation. This research provides mechanistic support for NAD+ supplementation in cardiovascular aging, directly validating the therapeutic rationale for NMN. The findings suggest NAD+ restoration could help prevent or slow progression of this common age-related heart condition that currently lacks effective drug treatments.
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New research in European Heart Journal shows declining NAD+ drives heart valve calcification, supporting NMN supplementation for cardiovascular aging prevention.