This review article examined the evidence supporting the use of tripeptide and hexapeptide formulations, particularly GHK-Cu, in topical skincare products for esthetic applications (evidence level: review of clinical and in vitro studies). The review synthesized existing research on how these peptides function in skin formulations, including their purported mechanisms related to collagen production and skin appearance. The article provides an overview of the scientific basis behind peptide-containing skincare products used in esthetic practice.