This animal model study investigated how methylene blue affects spatial working memory recovery in mice following traumatic brain injury, finding that the compound protected memory function by modulating the mitochondrial quality control system (including autophagy and mitophagy pathways). Researchers observed that methylene blue treatment improved performance on spatial working memory tasks and influenced key markers of mitochondrial homeostasis in brain tissue after injury. The evidence is from an animal model (mouse) study and does not establish effects in human patients.
Read more on Bulletin of experimental biology and medicine →