Researchers developed a targeted drug delivery system that uses NMN (a compound that boosts cellular energy) to treat kidney damage caused by reduced blood flow. In mouse studies, this system successfully delivered NMN directly to injured kidney cells, restored their energy production, and prevented both immediate kidney damage and long-term scarring. The treatment works by boosting NAD+ levels in kidney cells, which helps repair their cellular powerhouses (mitochondria).
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NMN-loaded nanocarriers restored mitochondrial function and reduced renal fibrosis in a mouse IRI model, suggesting NAD+ repletion may support kidney recovery.
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