Nicotinamide mononucleotide (NMN) improves the ovarian microenvironment associated with oocyte quality by increasing estrogen signaling, reprogramming ovarian metabolism, reducing oxidative stress, and inhibiting apoptosis in the spotted scat (Scatophagus argus).

This animal study in spotted scat fish demonstrated that NMN injections significantly improved ovarian function by increasing NAD+ levels and estrogen production. The treatment enhanced glucose and lipid metabolism, reduced oxidative stress, and improved mitochondrial function in ovarian tissue. Key findings included upregulation of steroidogenesis genes, increased antioxidant capacity, and reduced cellular death pathways, all contributing to better oocyte quality and reproductive health.

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