This groundbreaking study in C. elegans worms demonstrates that GHK-Cu significantly extends lifespan and improves multiple age-related health markers including stress resistance, mobility, and cellular function. The research identified specific molecular mechanisms: GHK-Cu preserves mitochondrial function by increasing membrane potential and promoting cellular energy production, while activating key longevity pathways (DAF-16 and SKN-1) that regulate antioxidant defenses. This is the first study to provide mechanistic evidence for GHK-Cu’s anti-aging effects through coordinated mitochondrial and cellular pathway regulation. The findings establish GHK-Cu as a validated geroprotective compound with defined molecular targets for anti-aging interventions.
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New research shows GHK-Cu extends lifespan and improves age-related health markers by preserving mitochondrial function and activating key longevity pathways.