This review article examines the topical application of GHK (glycine-histidine-lysine), a copper-binding tripeptide, as a potential anti-wrinkle agent, discussing its proposed mechanisms of action, demonstrated advantages, identified limitations, and future research directions (evidence level: review article). The authors analyze existing evidence regarding GHK’s effects on skin aging, collagen production, and wound healing while identifying practical challenges such as stability, formulation, and penetration barriers that affect its clinical utility. The review synthesizes current knowledge to outline prospects for advancing GHK-based skincare products, though it does not establish definitive clinical efficacy due to its review nature rather than original research findings.